The Hammerman lab is focused on the discovery of therapeutically relevant genomic alterations in lung and head and neck cancers. We apply next-generation sequencing techniques and large scale functional screens to identify genes and pathways which are important in the biology of these diseases. Our principal goal is to use these technologies to provide important insights into how to better treat lung and head and neck cancers and to both improve the prognosis for patients with these diseases and reduce morbidity from treatment. Of particular interest for us is how tumor cells and the tumor microenvironment adapt to cancer therapies and how we might target these adaptive mechanisms to extend the efficacy of cancer treatments.
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