{"id":403121,"date":"2023-07-10T14:22:25","date_gmt":"2023-07-10T06:22:25","guid":{"rendered":"\/\/m.catawbaoil.com\/403121.html"},"modified":"2023-07-10T14:22:25","modified_gmt":"2023-07-10T06:22:25","slug":"dierjieadcjioulianyaoquanqiuchuangxinfenghui_menpiaoyouhui","status":"publish","type":"post","link":"\/\/m.catawbaoil.com\/403121.html","title":{"rendered":"\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a_\u95e8\u7968\u4f18\u60e0"},"content":{"rendered":"<div  class=\"con_box\">\n<p><img decoding=\"async\" alt=\"\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a\" src=\"https:\/\/pic.huodongjia.com\/postevent\/2023-07-10\/1688969199.48.png\"\/><\/p>\n<p>\u4ece\u6297\u4f53\u5230ADC\uff0c\u4ece\u5c0f\u5206\u5b50<a href=\"https:\/\/www.huodongjia.com\/tag\/36575\/\">\u5076\u8054\u836f<\/a>\u7269\u5230BTCs\uff0c\u4ece\u9776\u5411TAA\u5230\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\uff1b\u9b54\u6cd5\u7684\u80cc\u540e\u662f\u6280\u672f\u7684\u8fed\u4ee3\u548c\u79d1\u5b66\u5bb6\u4eec\u65e0\u6570\u6b21\u601d\u7ef4\u78b0\u649e\u7684\u4ea7\u7269\u3002<\/p>\n<p>\u7eb5\u89c2\u6297\u4f53\u836f\u7684\u53d1\u5c55\u53f2\uff0c\u6cbb\u7597\u6027\u6297\u4f53\u7684\u5e02\u573a\u4efd\u989d\u6b63\u5728\u8fdb\u5165\u6307\u6570\u578b\u589e\u957f\u3002\u5c31ADC\u800c\u8a00\uff0c\u76ee\u524d\u5168\u7403\u81f3\u5c11\u67091400\u9879ADC\u7684\u4e34\u5e8a\u8bd5\u9a8c\u6b63\u5728\u8fdb\u884c\u4e2d\u3002\u5728 \u8fc7\u53bb\u4e24\u5e74\u91cc\uff0c87\u6b3e\u65b0ADC\u836f\u7269\u8fdb\u5165\u4e34\u5e8a\u5f00\u53d1\u9636\u6bb5\uff0c46\u6b3e\u6765\u81ea\u4e9a\u6d32\uff0c32\u6b3e\u6765\u81ea\u7f8e\u56fd\uff0c9\u6b3e\u6765\u81ea\u6b27\u6d32\u3002<\/p>\n<p>\u540c\u671f\uff0c\u622a\u81f3\u4eca\u5e745\u670812\u65e5\uff0c\u5728ADC\u9886\u57df\u7684\u6388\u6743\u5408\u4f5c\u8d85\u8fc720\u8d77\uff0c\u5305\u62ec\u767e\u65f6\u7f8e\u65bd\u8d35\u5b9d\u3001\u963f\u65af\u5229\u5eb7\u3001BioNTech\u548c\u5b89\u8fdb\u7b49\u5927\u836f\u4f01\u548c\u5927\u578b\u751f\u7269\u6280\u672f\u516c<\/p>\n<p>\u53f8\u3002\u4e2d\u56fd\u5728\u8fd9\u5927\u6f6e\u4e2d\u4e5f\u8868\u73b0\u7a81\u51fa\uff0c\u591a\u5bb6\u4e2d\u56fd\u533b\u836f\u516c\u53f8\u5f00\u53d1\u7684\u5019\u9009ADC\u7597\u6cd5\u5b8c\u6210\u6d77\u5916\u6388\u6743\uff0c\u56fd\u5185\u5916\u65e5\u8d8b\u6210\u719f\u7684\u5404\u79cd\u53cc\/\u591a\u6297\u53ca\u5176\u6280\u672f\u5e73\u53f0\u6b63\u5728\u8fce<\/p>\n<p>\u6765\u8d8a\u6765\u8d8a\u5e7f\u9614\u7684\u5f00\u53d1\u7a7a\u95f4\u548c\u5e02\u573a\u7a7a\u95f4\u3002<\/p>\n<p>l\u00a0\u4ee5\u7ec8\u4e3a\u59cb\uff0c\u6982\u5ff5\u5982\u4f55\u5feb\u901f\u62b5\u8fbe\u4e34\u5e8a\uff0c\u6ee1\u8db3\u60a3\u8005\u9700\u6c42\uff1f<\/p>\n<p>l\u00a0\u5982\u4f55\u6839\u636e\u9002\u5e94\u75c7\u548c\u9776\u70b9\u6765\u82b1\u5f0f\u7ec4\u5408\u6297\u4f53\u3001linker\u548cpayload\uff1f<\/p>\n<p>l\u00a0\u4ece\u7814\u53d1\u5230\u4e34\u5e8a\uff0cCMC\u5de5\u827a\u5f00\u53d1\u5982\u4f55\u52a0\u901f\u8fd9\u4e2a\u8fc7\u7a0b\uff1f<\/p>\n<p>l\u00a0\u56fd\u5185\u5916\u53c8\u6709\u54ea\u4e9b\u4f01\u4e1a\u5728\u4e0d\u65ad\u5b9e\u73b0\u65b0\u7684\u7a81\u7834\uff1f<\/p>\n<p>\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a\u5347\u7ea7\u518d\u51fa\u53d1\uff01\u672c\u5c4a\u5c06\u7f51\u7f57\u56fd\u5185\u5916\u4ee3\u8868\u4f01\u4e1a\u4ee3\u8868\u4eba\u7269\uff0c\u4e3a\u884c\u4e1a\u5e26\u6765\u4e00\u573a\u65b0\u578b\u836f\u7269\u7684\u76db\u5bb4\u3002<\/p>\n<p style=\"text-align:center\"><strong>\u5927\u4f1a\u4fe1\u606f<\/strong><\/p>\n<p>\u4f1a\u8bae\u4e3b\u9898 |\u00a0\u8ba9\u521b\u65b0\u836f\u4e0d\u88ab\u5b9a\u4e49<\/p>\n<p>\u4f1a\u8bae\u65f6\u95f4 |\u00a02023\u5e749\u670821-22\u65e5\uff08\u5468\u56db\u5468\u4e94\uff09<\/p>\n<p>\u4f1a\u8bae\u5730\u70b9 |\u00a0\u6c5f\u82cf\u00b7\u65e0\u9521<\/p>\n<p>\u4f1a\u8bae\u89c4\u6a21 |\u00a0800\u4eba<\/p>\n<p>\u4e3b\u529e\u5355\u4f4d |\u00a0\u65e0\u9521\u9ad8\u65b0\u533a\u7ba1\u59d4\u4f1a\u3001\u836f\u660e\u751f\u7269\u3001\u836f\u660e\u5408\u8054\u3001\u4f70\u50b2\u8c37BioValley<\/p>\n<p>\u652f\u6301\u5355\u4f4d |\u00a0\u542f\u5fb7\u533b\u836f\u3001\u540c\u5b9c\u533b\u836f\u3001\u591a\u79a7\u751f\u7269\u3001\u5b9c\u8054\u751f\u7269\u3001\u4e50\u666e\u751f\u7269\u3001\u201c\u79d1\u521b\u4e2d\u56fd\u201d\u751f\u7269\u533b\u836f\u4ea7\u4e1a\u79d1\u6280\u670d\u52a1\u56e2\u3001\u7f8e\u56fd\u534e\u4eba\u751f\u7269\u533b\u836f\u79d1\u6280\u534f\u4f1a\uff08CBA\uff09<\/p>\n<p>\u4f1a\u524d\u6d3b\u52a8\u00a0|\u00a09\u670820\u65e5 \u836f\u660e\u5408\u8054\u65b0\u5546\u4e1a\u5316\u5382\u623f\u6295\u4ea7\u5e86\u5178\u00a0<\/p>\n<p>\u540c\u671f\u6d3b\u52a8\u00a0|\u00a09\u670821\u65e5 \u9ad8\u7aef\u9886\u8896\u95ed\u95e8\u4f1a\u8bae\u3001\u9ad8\u7aef\u9886\u8896\u5609\u5bbe\u665a\u5bb4<\/p>\n<p style=\"text-align:center\"><strong>\u9996\u6279\u5609\u5bbe\u9635\u5bb9\u91cd\u78c5\u5267\u900f<\/strong><\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a\" src=\"https:\/\/pic.huodongjia.com\/postevent\/2023-07-10\/1688969233.11.png\"\/><\/p>\n<p style=\"text-align:center\"><strong>\u5927\u4f1a\u65e5\u7a0b<\/strong><\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a\" src=\"https:\/\/pic.huodongjia.com\/postevent\/2023-07-10\/1688969274.13.png\"\/><\/p>\n<p>\u4e3b\u8bba\u575b\uff1a\u5168\u4f53\u5927\u4f1a<\/p>\n<p>\u5168\u7403\u65b0\u578b\u6297\u80bf\u7624\u836f\u7269\u7814\u53d1\u8fdb\u5c55\u53ca\u8d8b\u52bf<\/p>\n<p>ADC\u836f\u7269Linker\u4e0epayload\u5168\u7403\u4e13\u5229\u5e03\u5c40\u5206\u6790<\/p>\n<p>PSMA target and the clinical outcome<\/p>\n<p>\u4ece\u4e34\u5e8a\u89d2\u5ea6\u770b\u5076\u8054\u7c7b\u836f\u7269\u7684\u53ef\u671f\u672a\u6765<\/p>\n<p>Panel\uff1a\u5f00\u653e\u5171\u4eab\uff0c\u62d2\u7edd\u5185\u5377\u2e3a\u5982\u4f55\u6253\u9020ADC\u836f\u7269\u5168\u7403\u4ea7\u4e1a\u751f\u6001\u5708<\/p>\n<p>Bispecific Antibody Drug Conjugates for the Treatment of Acute Myeloid Leukemia \u2013 A Safer &amp; More Efficacious Option for Patients?<\/p>\n<p>\u00a0<\/p>\n<p>\u8bba\u575b\u4e00\uff1aADC\u836f\u7269\u7814\u53d1\u4e0e\u4e34\u5e8a<\/p>\n<p>ADC\u673a\u5236\u4e0e\u4e34\u5e8a\u5b9e\u8df5\u63a2\u8ba8<\/p>\n<p>\u9776\u5411ROR1\u7684CS5001\u7684\u4e34\u5e8a\u5e94\u7528\u8fdb\u5c55\u548c\u672a\u6765\u9884\u671f<\/p>\n<p>\u9776\u5411\u53f6\u9178\u53d7\u4f53\u03b1\uff08FR\u03b1\uff09\u7684\u6297\u4f53\u5076\u8054\u836f\u7269\u7814\u53d1<\/p>\n<p>\u9776\u5411 Claudin 18.2 ADC\u836f\u7269\u7684\u5f00\u53d1\u7b56\u7565\u548c\u7ba1\u7ebf\u7814\u7a76<\/p>\n<p>AI Assisted Target Validation in ADC Discovery<\/p>\n<p>ADC\u836f\u7269\u7406\u60f3\u7684DAR\u503c\u63a7\u5236\u7b56\u7565<\/p>\n<p>\u7cd6\u94fe\u5b9a\u70b9\u5076\u8054\u65b0\u7b56\u7565\u5b9e\u73b0ADC\u5316\u5408\u7269\u7684\u4e00\u6b65\u5236\u5907<\/p>\n<p>PBD\u4e8c\u805a\u4f53\uff1aADC\u836f\u7269\u7684\u4f18\u9009\u5408\u91d1\u5f39\u5934<\/p>\n<p>ADC\u6bd2\u7d20\u7279\u5f81\u53ca\u5076\u8054\u65b9\u5f0f<\/p>\n<p>\u9776\u5411Trop-2ADC\u836f\u7269\u7684\u4e34\u5e8a\u8fdb\u5c55<\/p>\n<p>\u540eDS8201\u65f6\u4ee3\uff0c\u7b2c\u56db\u4ee3ADC\u836f\u7269\u7684\u8bbe\u8ba1\u4e0e\u7814\u53d1\u601d\u8def<\/p>\n<p>\u9776\u5411CDH6\u7684ADC\u836f\u7269\u5f00\u53d1\u6539\u9020\u7b56\u7565<\/p>\n<p>AI\u8ba1\u7b97\u5728\u5076\u8054\u836f\u7269\u8bbe\u8ba1\u4e2d\u7684\u5e94\u7528<\/p>\n<p>\u57fa\u4e8e\u5b9a\u70b9\u5076\u8054\u6280\u672f\u7684ADC\u5f00\u53d1\u6311\u6218<\/p>\n<p>\u57fa\u4e8e\u80bd\u63a5\u5934\u6280\u672f\u5b9e\u73b0\u7684\u66f4\u7a33\u5b9a\u7684ADC\u836f\u7269\u5f00\u53d1<\/p>\n<p>\u57fa\u4e8eFtase\u9176\u5b9a\u70b9\u5076\u8054\u7684ADC\u836f\u7269\u5f00\u53d1<\/p>\n<p>\u9ad8\u6bd2\u7d20Payload\u7684\u5076\u8054\u7b56\u7565<\/p>\n<p>\u9176\u4fc3\u5b9a\u70b9\u5076\u8054\u6280\u672f\u5728ADC\u836f\u7269\u4e2d\u7684\u5e94\u7528<\/p>\n<p>\u5229\u7528\u9176\u5316\u5b66\u4e00\u6b65\u7cd6\u57fa\u5076\u8054\u7b56\u7565\uff08YTConjuTM\uff09\u6784\u5efa\u591a\u7279\u5f02\u6027\u5076\u8054\u836f\u7269<\/p>\n<p>ADC\u836f\u7269\u667a\u80fd\u7814\u53d1\u4e0e\u751f\u4ea7<\/p>\n<p>\u00a0<\/p>\n<p>\u8bba\u575b\u4e8c\uff1a\u5076\u8054\u836f\u7269\u65b0\u7ec4\u5408<\/p>\n<p>\u53cc\u6297ADC\u836f\u7269\u7684\u7814\u53d1\u8fdb\u5c55\u53ca\u9690\u60a3<\/p>\n<p>\u53cc\u6297ADC\u5728\u5b9e\u4f53\u7624\u4e2d\u7684\u4e34\u5e8a\u8fdb\u5c55<\/p>\n<p>\u521b\u65b0\u591a\u80bd\u9012\u836f\u7cfb\u7edf\u7684\u5f00\u53d1<\/p>\n<p>\u53cc\u9776\u5411XDC\u6280\u672f\u8d4b\u80fd\u9776\u5411\u836f\u7269\u518d\u6500\u9ad8\u5cf0<\/p>\n<p>\u5c0f\u6838\u9178\u5076\u8054\u836f\u7269\u7528\u4e8e\u6838\u9178\u7684\u809d\u5916\u9012\u9001<\/p>\n<p>\u5c0f\u5206\u5b50\u5076\u8054\u836f\u7269\uff08SMDC\uff09\u5982\u4f55\u7a81\u51fa\u91cd\u56f4\uff1f<\/p>\n<p>\u9776\u5411MUC1-EGFR\u7684\u53cc\u6297ADC\u836f\u7269\u7814\u53d1<\/p>\n<p>PDC\u836f\u7269\u2e3aADC\u4e4b\u540e\u7684\u4e0b\u4e00\u4e2a\u201c\u9ec4\u91d1\u65b0\u8d5b\u9053\u201d<\/p>\n<p>PDC\u836f\u7269\u7684\u9776\u5411\u91ca\u653e\u539f\u7406\u4e0e\u4ee3\u8c22\u4ea7\u7269\u9274\u5b9a\u7814\u7a76\u7b56\u7565<\/p>\n<p>\u6838\u6765\u6838\u53bb\u2e3aRDC\u836f\u7269\u7684\u5168\u7403\u7814\u53d1\u8fdb\u5c55<\/p>\n<p>\u653e\u5c04\u6027\u836f\u7269RDC\u7684\u8f6c\u5316\u548c\u4e34\u5e8a\u7814\u7a76<\/p>\n<p>PROTAC+ADC\uff1dDAC(\u5b9a\u5411\u964d\u89e3\u6297\u4f53\u5076\u8054\u7269)\u7684\u4f5c\u7528\u673a\u5236<\/p>\n<p>\u00a0<\/p>\n<p>\u8bba\u575b\u4e09\uff1a\u65b0\u578b\u5076\u8054\u836f\u7269CMC\u4e0e\u5546\u4e1a\u5316<\/p>\n<p>\u5bcc\u6709\u6311\u6218\u7684ADC\u5c0f\u5206\u5b50CMC\u5e94\u5bf9\u4e4b\u7b56<\/p>\n<p>ADC\u6709\u6548\u8f7d\u8377\uff08payload\uff09\u7684\u5236\u5907\u5de5\u827a<\/p>\n<p>ADC\u836f\u7269\u4e2d\u7f8eIND, CTA, BLA\/NDA, MAA\u7533\u62a5\u7b56\u7565\u53ca\u96be\u70b9\u5206\u6790<\/p>\n<p>ADC\u836f\u7269\u7684\u6280\u672f\u8f6c\u79fb\u96be\u70b9<\/p>\n<p>ADC\u836f\u7269\u7684\u5de5\u827a\u653e\u5927\u4e0e\u5546\u4e1a\u5316\u751f\u4ea7\u7b56\u7565<\/p>\n<p>\u521b\u65b0\u836f\u89c4\u8303\u5316\u6807\u51c6\u5316\u5de5\u4e1a\u751f\u4ea7\u4f53\u7cfbGMP\u7684\u5efa\u7acb<\/p>\n<p>\u7f8e\u56fd\u836f\u5178\u591a\u80bd\u836f\u7269\u7684\u6807\u51c6\u53ca\u8fdb\u5c55<\/p>\n<p>ADC\u836f\u7269\u751f\u4ea7\u53ca\u7a33\u5b9a\u6027\u8bc4\u4f30<\/p>\n<p>ADC\u6bd2\u7d20\u5904\u7406\u7b56\u7565\u53ca\u4e0b\u6e38\u5de5\u5e8f<\/p>\n<p>FDA\u4e0a\u5e02ADC\u836f\u7269BLA\u5ba1\u8bc4\u8981\u70b9\u53ca\u9000\u5ba1\u53d1\u8865\u89e3\u6790<\/p>\n<p>ADC\u836f\u7269\u7684\u8d28\u91cf\u6807\u51c6\u5236\u5b9a\u4e0e\u5206\u6790\u7b56\u7565<\/p>\n<p>\u6280\u672f\u4e3a\u5148--\u5982\u4f55\u89e3\u9501\u56fd\u5185ADC\u836f\u7269\u5546\u4e1a\u5316\u65b0\u6a21\u5f0f<\/p>\n<p>ADC\u836f\u7269\u5f00\u53d1\u8fc7\u7a0b\u4e2dCMC\u6311\u6218\u53ca\u5e94\u5bf9\u7b56\u7565<\/p>\n<p>\u53cc\/\u591a\u7279\u5f02\u6027\u6297\u4f53\u7ed3\u6784\u7684\u591a\u6837\u6027\u5e26\u6765\u7684\u751f\u4ea7\u4e0a\u7684\u6311\u6218<\/p>\n<p>\u591a\u80bd\u5076\u8054\u836f\u7269\uff08PDC\uff09\u7684CMC\u8981\u70b9\u53ca\u96be\u70b9<\/p>\n<p>ADC characterization challenges<\/p>\n<p>ADC\u7684\u51bb\u5e72\u751f\u4ea7\u5de5\u827a<\/p>\n<p>Panel\uff1a\u56fd\u4ea7ADC\u51fa\u6d77\u72c2\u6f6e\u80fd\u5426\u201c\u4e00\u8def\u751f\u82b1\u201d\uff1f<\/p>\n<p>\u00a0<\/p>\n<p>\u53c2\u4f1a\u62a5\u540d<\/p>\n<p>\u2590\u00a0\u53c2\u4f1a\u4eba\u7fa4<\/p>\n<p><img decoding=\"async\" alt=\"\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a\" src=\"https:\/\/pic.huodongjia.com\/postevent\/2023-07-10\/1688969307.58.png\"\/><\/p>\n<p>\u00a0<\/p>\n<p style=\"text-align:center\">\u00a0<\/p>\n<p style=\"text-align:center\"><strong>\u5a92\u4f53\u652f\u6301<\/strong><\/p>\n<p style=\"text-align:center\"><img decoding=\"async\" alt=\"\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a\" src=\"https:\/\/pic.huodongjia.com\/postevent\/2023-07-10\/1688969379.43.png\"\/><\/p>\n<p>\u00a0<\/p>\n<\/p><\/div>\n<p><a href=\"https:\/\/www.huodongjia.com\/event-77000742.html\">https:\/\/www.huodongjia.com\/event-77000742.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4ece\u6297\u4f53\u5230ADC\uff0c\u4ece\u5c0f\u5206\u5b50\u5076\u8054\u836f\u7269\u5230BTCs\uff0c\u4ece\u9776\u5411TAA\u5230\u9776\u5411\u80bf\u7624\u5fae\u73af\u5883\uff1b\u9b54\u6cd5\u7684\u80cc\u540e\u662f\u6280\u672f\u7684\u8fed\u4ee3\u548c\u79d1\u5b66\u5bb6\u4eec\u65e0\u6570...<\/p>\n<p class=\"more-link-wrap\"><a href=\"\/\/m.catawbaoil.com\/403121.html\" class=\"more-link\">Read More<span class=\"screen-reader-text\"> &ldquo;\u7b2c\u4e8c\u5c4aADC\u53ca\u5076\u8054\u836f\u5168\u7403\u521b\u65b0\u5cf0\u4f1a_\u95e8\u7968\u4f18\u60e0&rdquo;<\/span> &raquo;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6111],"tags":[],"class_list":["post-403121","post","type-post","status-publish","format-standard","hentry","category-huiyi"],"_links":{"self":[{"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/posts\/403121"}],"collection":[{"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/comments?post=403121"}],"version-history":[{"count":0,"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/posts\/403121\/revisions"}],"wp:attachment":[{"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/media?parent=403121"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/categories?post=403121"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.catawbaoil.com\/wp-json\/wp\/v2\/tags?post=403121"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}